This paper presents an approach that integrates and improves responses to cultural, gender and human rights issues in programming. The approach builds on the experience of the United Nations Country Team (UNCT) in creating a United Nations Development Assistance Framework (UNDAF) for Mozambique, a pilot country for the United Nations goal of "Delivering as One", as well as on the UNESCO/UNFPA experience of piloting an integrated approach to mainstreaming culture, gender and human rights in district-level planning exercises. Although created in Mozambique, the framework is intended to be suitable for the design, implementation and evaluation of development programs around the world, as it addresses universal development issues.